Permeability is defined as the ability of drug entity to get absorbed through physiological membrane. It is one of the important parameter to achieve desired bioavability of drug in systemic circulation for therapeutic result. Poor intestinal membrane permeability is result of physiochemical properties of drug molecule and intestinal membrane properties which continues to be a major obstacle to the oral delivery of many molecules with potential therapeutic utility. Poorly absorbed drugs generally are of bcs class III and IV, often require high doses in order to reach therapeutic plasma concentrations after oral administration. The challenge over the years has been to design techniques that will allow oral administration of these drugs, irrespective of their properties, to achieve a therapeutic systemic availability. Potential therapeutic utility and ease of administration by oral route have triggered scientist to develop methods to alter the environment around the drug, the membrane barrier property and to utilize transport system across the membrane which enhances the permeability of poorly absorbed drugs. The purpose of this article is to describe the techniques of permeability enhancement for the attainment of effective absorption and improved bioavailability.
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